Publications

^GGraduate student, ^UUndergraduate Student, ^PPost-doctoral fellow

2022

^GRempel, S.K., ^UWelch, M.J., Ludwig, A.L., Phillips, J., ^UKancherla, Y., Zack, D.J., Gamm, D.M., and Gómez, T.M. (2022) Human photoreceptors switch from autonomous axon extension to cell-mediated process pulling during synaptic marker redistribution. Cell Reports. Cover article, May 17;39(7). PMID: 35584680.

2021

^GCatlett, T.S., ^UOnesto, M.M., ^UMcCann, A.J., ^GRempel, S.K., Glass, J., Franz, D.N., and Gómez, T.M. (2021) RhoA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex. Nat. Commun. 12(1):2589.

^GShort C.A., ^UOnesto M.M., ^GRempel S.K., ^GCatlett T.S., Gomez T.M. (2021) Familiar growth factors have diverse roles in neural network assembly. Curr Opin Neurobiol. 66:233-239.

^UOnesto M. M., ^GShort C.A., ^GRempel S.K., ^GCatlett T.S., Gomez T.M. (2021) Growth Factors as Axon Guidance Molecules: Lessons From in vitro Studies. Front Neurosci. 15:678454.

2020

Rigby M.J., Gomez T.M. and Puglielli L. (2020) Glial Cell-Axonal Growth Cone Interactions in Neurodevelopment and Regeneration. Front Neurosci. 14:203.

2019

Joshi DC, Zhang CL, Babujee L, Vevea JD, August BK, Sheng ZH, Chapman ER, Gomez TM, Chiu SY. (2019) Inappropriate Intrusion of an Axonal Mitochondrial Anchor into Dendrites Causes Neurodegeneration. Cell Rep. Oct 15;29(3):685-696.

^G Nichol RH 4th, ^G Catlett TS, ^U Onesto MM, ^U Hollender D, Gómez TM. (2019 ) Environmental Elasticity Regulates Cell-type Specific RHOA Signaling and Neuritogenesis of Human Neurons. Stem Cell Reports. Dec 10;13(6):1006-1021. Faculty of 1000 selection.

2018

Eno C., Gomez T.M., Slusarski D.C., Pelegri F. (2018) Slow calcium waves mediate furrow microtubule reorganization and germ plasm compaction in the early zebrafish embryo. Development. May 17;145(10). PMID: 29632136

2017

^G Kerstein PC, ^U Patel KM, Gomez TM Calpain-Mediated Proteolysis of Talin and FAK Regulates Adhesion Dynamics Necessary for Axon Guidance. (2017) J Neurosci. 2017 Feb 8;37(6):1568-1580.

2016

^G Nichol RH 4th, ^U Hagen KM, ^U Lumbard DC, Dent EW, Gómez T.M. (2016) Guidance of Axons by Local Coupling of Retrograde Flow to Point Contact Adhesions. J Neurosci. Feb 17;36(7):2267-82. PMID: 26888936.

^G Short CA, ^G Suarez-Zayas EA, Gomez TM.(2016) Cell adhesion and invasion mechanisms that guide developing axons. Curr Opin Neurobiol. Aug;39:77-85. PMID: 27135389.

^G Catlett TS, Gomez TM. Division of labor in the growth cone by DSCR1. J Cell Biol. (2016) May 23;213(4):407-9. PMID: 27216257.

2015

^GSantiago-Medina, M., ^UGregus, K. A., Nichol, R.H. and Gomez, T.M. (2015) Regulation of ECM degradation and axon guidance by growth cone invadosomes. Development, Feb 1, 142(3):486-496.Highlighted in Science magazine. Faculty of 1000 selection. PMCID: PMC4493769.

^GKerstein, P., ^GNichol, R., Gomez T.M. (2015) Mechanochemical regulation of growth cone motility. Front Cell Neurosci, Jul 7;9:244. PMCID: PMC 4493769.

2014

Gomez, T.M. and Letourneau, P.C. (2014). Actin Dynamics in growth cone motility and navigation.J Neurochem, Apr; 129(2):221-234. PMCID: PMC3980044.

Doers M.E., Musser M.T., ^GNichol R., Baker M.W., Berndt E.R., Gomez T.M., Zhang S.C.,Abbeduto L., Bhattacharyya A. (2014). Induced Pluripotent stem cell derived forebrain neurons from FXS individuals show defects in initial neurite outgrowth. Stem Cells Dev.March 24. 23 (15): 1777-1787. PMCID: PMC4103262.

Wang, Z.Y., McDowell, T., Wang, P., Alvarez, R., Gomez T.M., Bjorling, D.E. (2014) Activation of CB1 inhibits NGF-induced sensitization of TRPV1 in adult mouse afferent neurons.Neuroscience, Sep 26;277:679-89679-89689. PMCID: 25088915.

2013

^GKerstein, P., ^GJacques-Fricke, B., ^PRengifo J., Mogen, B., Williams, J., Gottlieb, P., Sachs, F.and Gomez, T.M. (2013) Mechanosensitive TRPC1 channels promote calpain proteolysis of talin to regulate spinal axon outgrowth. J Neurosci, Jan 2, 33(1): 273-285. PMCID: 3539200.

2012

^GMyers, J.P., ^GRobles, E., ^UDucharme-Smith, A. and Gomez, T.M. (2013) Focal adhesion kinase modulates CDC42 activity downstream of positive and negative axon guidance cues.J Cell Science. 125 (pt 12): 2918-2929. PMCID: 3434813.

2011

Hengen, K.B., Gomez, T.M., Stang K.M., Johnson, S.M. and Behan, M. (2011) Changes in ventral respiratory column GABAaR {varepsilon} and {delta} subunits during hibernation mediate resistance to depression by EtOH and pentobarbital. Am J Physiol and Regul IntegrCom Physiol. 2011 Feb; 300(2):R272-83. PMCID:3043800.

^GSantiago-Medina, M., ^GMyers, J.P. and Gomez T.M. (2011) Imaging adhesion and signaling dynamics in Xenopus Laevis growth cones. Dev. Neurobio. Apr; 72(4):585-599. PMCID:3158960.

^GMyers, J.P., ^GSantiago-Medina, M. and Gomez T.M. (2011) Regulation of axonal outgrowth and pathfinding by integrin-ECM interactions. Dev. Neurobio. 71 (11):901-923. PMCID:3192254.

Gomez, T.M. (2011) Pioneering studies on the mechanism of neuronal morphogenesis. Sep;71(9):78–784. Dev. Neurobio. PMCID: PMC3482615.

^GMyers, J.P. and Gomez, T.M. (2011) Focal adhesion kinase promotes integrin adhesion dynamics necessary for chemotrophic turning of nerve growth cones. J Neurosci.21 September; 31(38):13585-13595. PMCID: 3193056.

2010

^GMoon, M-S and Gomez, T.M. (2010) Balanced Vav2 GEF activity regulates neurite outgrowth and branching in vitro and in vivo. Mol. Cell. Neurosci. Jun; 44(2): 118-128.PMCID: 2862809.

2009

^GWoo, S. W., ^URowan, D.J. and Gomez, T.M. (2009) Retinotopic mapping requires FAK-mediated regulation of growth cone adhesion. J Neurosci. 29(44): 13981-13991.PMCID:2796108.

2008

Marriott, G., Mao, S., Sakata, T., Ran, J., Jackson, D.K., Petchprayoon, C., Gomez, T.M., Warp, E.,Tulyathan O., Aaron, H.L., Isacoff, E.Y. and Yan, Y. (2008). Optical lock-in detection imaging microscopy for contrast-enhanced imaging in living cells. Proc Natl Acad Sci USA. 105:17789-17794. PMCID: 2584753.

2006

Kholmanskikh, S. S., Koeller, H.B., Wynshaw-Boris, A., Gomez, T.M., Letourneau, P.C. and Ross, E.M. (2006). Calcium-dependent interaction of lis1 with IQGAP1 and CDC42 promotes neuronal motility. Natur Neurosci., 9, 50-57

Gomez, T.M. and Zheng, J. (2006). The molecular basis for calcium-dependent axon pathfinding. Nature Reviews Neuroscience, 7, 115-125.

^GWoo, S.W. and Gomez, T.M. (2006). Rac1 and RhoA promote neurite outgrowth through formation and stabilization of growth cone point contacts. J Neurosci. 26(5) 1418-1428.

^GJacques-Fricke, B.T., ^USeow, Y., Gottlieb, P.A., Sachs, F. and Gomez, T.M. (2006). Opposing regulation of neurite growth by Ca2+ influx through a mechanosensitive channel and release from intracellular stores. J Neurosci. 26(21), 5656-5664.

^GRobles, E. and Gomez, T.M. (2006). Focal adhesion kinase signaling at sites of integrin mediated adhesion controls axon pathfinding. Nature Neurosci., 9 (10), 1274-1283.

Pal, S., Jing, W., Murray J.T., Gellman, S.H., Wozniak, M.A. Keely, P.J., Bover, M.E., Gomez, T.M.,Hasso, S.M., Fallon, J.F. and Bresnick, E.H. (2006). An anti-angiogenic neurokinin-B/thromboxane A2 regulatory axis. J. Cell Bio., 174(7):1047-1058.

2005

Gomez, T.M. (2005). Neurobiology: channels for pathfinding. Nature. 434, 835-838.

^GRobles, E., ^GWoo, S and Gomez, T.M. (2005). Src-dependent tyrosine phosphorylation at the tips of growth cone filopodia promotes extension. J Neurosci. 25(33), 7669-7681.

^G Moon, M-s and Gomez, T.M. (2005). Adjacent pioneer commissural interneuron growth cones switch from contact avoidance to axon fasciculation after midline crossing. Devlp. Biol., 288, 474-486.

2004

Gomez, T.M., ^GRobles, E. (2004). The great escape: phosphorylation of Ena/VASP by PKA promotes filopodial formation. Neuron 42, 1-3.

2003

^GRobles, E., Huttenlocher, A, Gomez, T.M. (2003). Filopodial calcium transients regulate growth cone motility and guidance through local activation of calpain. Neuron, 38, 597-609.

As post-doctoral fellow:

Gomez, T.M. and Spitzer, N.C.(1999). In vivo regulation of axon extension and pathfinding by growth cone calcium transients. Nature 397, 350-355. (Mini-review in Neuron).

Spitzer, N.C., Lautermilch, N.J., Smith, R.D. and Gomez, T.M. (2000). Coding of neuronal differentiation by calcium transients. BioEssays. 22, 811-817.

Gomez, T.M., and Spitzer, N.C. (2000). Regulation of growth cone behavior by calcium:new dynamics to earlier perspectives. J Neurobiology. 44, 174-183.

Gomez, T.M., Robles, E., Poo, M-m and Spitzer, N.C.(2001). Filopodial calcium transients promote substrate-dependent growth cone turning. Science, 291, 1983-1987. (Comment in Scientific American)

As a Graduate Student:

Letourneau, P.C., Snow, D.M., and Gomez, T.M. (1994). Regulation of growth cone motility by substratum bound molecules and cytoplasmic [Ca2+]. Prog Brain Res 103, 85-98.

Gomez, T.M., and Letourneau, P.C. (1994). Filopodia initiate choices made by sensory neuron growth cones at laminin/fibronectin borders in vitro. J Neurosci 14,5959-5972.

Gomez, M.R., and Gomez, T.M. (1995). Regulation of cell migration and axon pathfinding assessed with experimental and disease models. Acta. Neuropediatria 1, 228-238.

Gomez, T.M., Snow, D.M., and Letourneau, P.C. (1995). Characterization of spontaneous calcium transients in nerve growth cones and their effect on growth cone migration. Neuron 14, 1233-1246.

Gomez, M.R., and Gomez, T.M. (1996). Experimental pathological models that explain the regulation of cellular migration and axon’s orientations. Rev Neurol 23, 1351-1355.

Gomez, T.M., Roche, F.K., and Letourneau, P.C. (1996) Chick sensory neuronal growth cones distinguish fibronectin from laminin by making substratum contacts that resemble focal contacts. J. Neurobiology 29, 18-34.