Credentials: PhD from CMB Oct 25, 2021
Position title: Scientist I, Boost Neuroscience
•Catlett, T.S., Onesto, M.M., McCann, A.J., Rempel, S.K., Glass, J., Franz, D.N., and Gómez, T.M. (2021) RhoA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex. Nat. Commun. 12(1):2589.
•Short C.A., Onesto M.M., Rempel S.K., Catlett T.S., Gomez T.M. (2021) Familiar growth factors have diverse roles in neural network assembly. Curr Opin Neurobiol. 66:233-239.
•Onesto M. M., Short C.A., Rempel S.K., Catlett T.S., Gomez T.M. (2021) Growth Factors as Axon Guidance Molecules: Lessons From in vitro Studies. Front Neurosci. 15:678454.
• Rempel, S.K., Welch, M.J., Ludwig, A.L., Phillips, J., Kancherla, Y., Zack, D.J., Gamm, D.M., and Gómez, T.M. (2022) Human photoreceptors switch from autonomous axon extension to cell-mediated process pulling during synaptic marker redistribution. Cell Reports. Cover article, May 17;39(7). PMID: 35584680.
I am interested in understanding how human stem cell-derived photoreceptors extend axons in vitro and in situ in 3D retinal organoids. These cells are promising candidates to use for cell transplant therapies to cure blindness caused by diseases such as cone/rod dystrophies and Age-related Macular Degeneration. By understanding how human photoreceptors develop in vitro and in human organoids, I hope to better understand aspects of normal human retinal development and to better inform transplant therapies.